USMLE-Rx Step 1 Practice Q's

USMLE-Rx Step 1 Qmax Challenge #3563

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USMLE-Rx Step 1 Qmax Challenge #3563A 32-year-old man presents with a painful ulcerated skin lesion (see image). A thorough history reveals weight loss as well as 4 years of intermittent diarrhea that is often bloody.

Other than a wound dressing, most appropriate therapy to address the underlying cause of this patient’s skin lesion?

A. Ampicillin
B. Bacitracin
C. Glipizide
D. Oral corticosteroids
E. Tetracycline

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USMLE-Rx Step 1 Qmax Challenge #3561

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USMLE-Rx Step 1 Qmax Challenge #3561A 27-year-old pregnant woman from Guatemala dies suddenly while lifting a heavy object in her home. She has no cardiac history, but her mother tells the coroner that her daughter developed a murmur 3 or 4 years ago. A histologic specimen of her heart at autopsy is shown in the image.

What is the most likely cause of this pathology and the patient’s death?

A. Atherosclerosis
B. Bicuspid aorta
C. Hypertrophic obstructive cardiomyopathy
D. Infectious endocarditis
E. Rheumatic heart disease

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USMLE-Rx Step 1 Qmax Challenge #3527

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USMLE-Rx Step 1 Qmax Challenge #3527A pregnant woman presents to her obstetrician for her first scheduled prenatal examination. Her uterus is larger than it should be for the gestational age of 10 weeks, as calculated on the basis of her last menstrual period. Her ?-human chorionic gonadotropin level is elevated to >100,000 mU/mL. A transvaginal ultrasound of the uterus is performed and is shown in the image.

What are the most common karyotype and the most usual chromosomal origin in this case?

A. 46,XO; both maternal and paternal derivations
B. 46,XX; all maternally derived
C. 46,XX; all paternally derived
D. 69,XXX; extra maternal set
E. 69,XXY; extra paternal set

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USMLE-Rx Step 1 Qmax Challenge #3508

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USMLE-Rx Step 1 Qmax Challenge #3508Several days after a bioterrorist attack with an unidentified pathogen, patients begin presenting to emergency departments with shortness of breath, fever, and acidosis. Chest films are obtained, an example of which is shown in the image. Biopsy of this area shows necrosis.

The mechanism of action of this pathogen’s toxin is similar to that of which of the following organisms?

A. Mycobacterium avium-intracellulare
B. Mycobacterium tuberculosis
C. Strongyloides stercoralis
D. Vibrio cholerae

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USMLE-Rx Step 1 Qmax Challenge #3498

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USMLE-Rx Step 1 Qmax Challenge #3498A 35-year-old woman presents to the emergency department because of abdominal pain and diarrhea mixed with mucus and blood. She also has ulcerated lesions with violaceous borders on her legs. Gross blood is present on rectal examination. A biopsy of her colon reveals inflammation confined to the mucosa and submucosa, as shown in the image.

Which of the following would most likely be used to treat this patient?

A. Infliximab
B. Nizatidine
C. Omeprazole
D. Ondansetron
E. Sucralfate
F. Sulfasalazine

———————–

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USMLE-Rx Step 1 Qmax Challenge #3493

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USMLE-Rx Step 1 Qmax Challenge #3493A 45-year-old man presents with a low-grade fever, hoarseness, cough, and a sore throat. On physical examination, he has swollen cervical lymph nodes. Gram stain of his sputum is obtained, and the specimen is shown in the image. Secretions obtained from the patient’s tonsils are analyzed using polymerase chain reaction, and a diagnostic protein subunit is found.

The exotoxin responsible for his symptoms inhibits protein synthesis by which of the following mechanisms?

A. Activation of adenyl cyclase by adenosine diphosphate ribosylation
B. Activation of Gs
C. Adenosine diphosphate ribosylation of elongation factor 2
D. Inhibition of Gi
E. Stimulating macrophages to release tumor necrosis factor-?

———————–

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USMLE-Rx Step 1 Qmax Challenge #3488

8

Check out today’s Step 1 Qmax Question Challenge.

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USMLE-Rx Step 1 Qmax Challenge #3488A 33-year-old woman presents to her physician complaining of fatigue and joint aches. On physical examination, her doctor notices abnormalities in her skin, which are seen in the image. Laboratory studies show antinuclear and anti-Sm antibodies. Urinalysis shows RBC casts and 2.1 g protein per 24 hours. A renal biopsy is performed.

Which of the following diseases has a similar cellular mechanism of disease progress?

A. Acute serum sickness
B. Cellulitis
C. Cervical carcinoma
D. Contact dermatitis
E. Goodpasture’s disease
F. Graves’ disease

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Want to know the ‘bottom line?’ Purchase a USMLE-Rx Subscription and get many more features, more questions, and passages from First Aid, including images, references, and other facts relevant to this question.

This practice question is an actual question from the USMLE-Rx Step 1 test bank. For more USMLE Step 1 prep, subscribe to our Flash Facts and Step 1 Express video series. Score the best deal on all three products with a Step 1 Triple Play Bundle.

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