USMLE-Rx Step 1 Practice Q's

 

USMLE-Rx Step 1 Qmax Challenge #4460

4

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USMLE-Rx Step 1 Qmax Challenge #4460A concerned mother brings her 5-year-old son to the pediatrician’s office. She explains that the child has been healthy since birth, but has recently begun to have difficulty standing up. In the office, the physician notices that when the child wants to stand up, he uses his hands and arms to push himself to a standing position, as shown in the image. He is diagnosed with a genetic condition.

Which other disorder shares the same inheritance pattern as this patient’s genetic disease?

A. Cystic fibrosis
B. Hemochromatosis
C. Hemophilia A
D. Marfan’s syndrome
E. Neurofibromatosis type 1

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USMLE-Rx Step 1 Qmax Challenge #4426

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USMLE-Rx Step 1 Qmax Challenge #4426A loss of function mutation affecting a particular tumor suppressor gene causes the bilateral lesions shown in the image.

On which chromosome is this tumor suppressor gene found?

A. 5q
B. 11q
C. 13q
D. 17p
E. 22q

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USMLE-Rx Step 1 Qmax Challenge #4423

4

Check out today’s Step 1 Qmax Question Challenge.

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A 25-year-old woman presents to her primary care physician with frequent headaches that worsen when she bends over. She says that she often burns the back of her arms while cooking but never notices until her husband says something. She has looked up her symptoms online, and is very worried that she has MS. She is referred to a neurologist, where an MRI reveals the congenital anatomical malformation seen below.

Sensory deficits are due to impingement upon which part of the spinal cord?

A. Anterior horn cells
B. Dorsal columns
C. Dorsal root ganglia
D. Spinocerebellar tract
E. Spinothalamic tract

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This practice question is an actual question from the USMLE-Rx Step 1 test bank. For more USMLE Step 1 prep, subscribe to our Flash Facts and Step 1 Express video series. Score the best deal on all three products with a Step 1 Triple Play Bundle.USMLE-Rx Step 1 Qmax Challenge #4423

 

USMLE-Rx Step 1 Qmax Challenge #4171

5

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USMLE-Rx Step 1 Qmax Challenge #4171A 45-year-old white man complains of several months of worsening shortness of breath. Previously he was diagnosed with asthma because he was having intermittent episodes of wheezing combined with a productive cough and difficulty catching his breath. He used to run 2 miles every morning but can no longer walk more than 10 city blocks without stopping. He has never smoked. He is using his accessory muscles to assist with respiration. Pulmonary examination is notable for a decreased ratio of forced expiratory volume in 1 second to forced vital capacity, decreased air movement with each breath, and increased resonance on percussion. X-ray of the chest is shown in the image.

Which of the following is the most likely underlying cause for this patient’s disease?

A. A genetic mutation resulting in deficient levels of a protease
B. A genetic mutation resulting in deficient levels of a protease inhibitor
C. A mutation in the p53 gene
D. A mutation of the CFTR gene, which encodes a regulated chloride channel
E. Airway inflammation, airflow obstruction, and bronchial hyperresponsiveness

———————–

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USMLE-Rx Step 1 Qmax Challenge #4161

6

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USMLE-Rx Step 1 Qmax Challenge #4161The kidneys of a 65-year-old patient with long-standing diabetes mellitus are examined at autopsy. One kidney is shown in the image. In the later stage of his disease, this patient frequently required a Foley catheter to adequately drain his bladder.

What condition most likely caused the anomalous appearance of his kidneys?

A. Acute pyelonephritis
B. Chronic reflux-associated pyelonephritis
C. Drug-induced interstitial nephritis
D. Hypertension
E. Minimal change disease

———————–

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USMLE-Rx Step 1 Qmax Challenge #4157

8

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USMLE-Rx Step 1 Qmax Challenge #4157A 36-year-old African-American man is prescribed trimethoprim-sulfamethoxazole for a bacterial infection. Three days after starting the drug, he returns to the clinic complaining of fatigue and shortness of breath. Physical examination is notable for the findings shown in the image.

Underproduction of which of the following molecules is most likely responsible for this patient’s reaction to the drug?

A. ?-Globin chain
B. Glucose-6-phosphate
C. Phosphoribosyl pyrophosphate
D. Reactive oxygen species
E. Reduced glutathione

———————–

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USMLE-Rx Step 1 Qmax Challenge #4155

9

Check out today’s Step 1 Qmax Question Challenge.

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USMLE-Rx Step 1 Qmax Challenge #4155A 3-month-old child is brought to his pediatrician’s office for a check-up. The child has a rather pale complexion. He has a social smile but does not hold his head up on his own or make noises. Brisk reflexes are noted in the upper and lower extremities, and he has a rash, as shown in the image. The mother reports that she has to change his clothes several times daily because of a strange odor.

What is the most appropriate treatment for the condition the infant most likely has?

A. A diet low in isoleucine and leucine
B. A diet low in phenylalanine
C. A diet low in tyrosine
D. A high-protein diet
E. Recombinant enzyme therapy

———————–

Want to know the ‘bottom line?’ Purchase a USMLE-Rx Subscription and get many more features, more questions, and passages from First Aid, including images, references, and other facts relevant to this question.

This practice question is an actual question from the USMLE-Rx Step 1 test bank. For more USMLE Step 1 prep, subscribe to our Flash Facts and Step 1 Express video series. Score the best deal on all three products with a Step 1 Triple Play Bundle.

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